The Littles are a race of little people with tails and pointed ears that are rarely seen by humans and live in the walls of the Biggs home. Life is peaceful until Mr. and Mrs. Biggs get lost in Africa, forcing their son, Henry to live with his mean Uncle Augustus. As Henry is packing, Tom and Lucy Little fall into the suitcase and end up in the unfamiliar and frightening world of Augustus. The kids soon discover Augustus wants to be Henry's guardian so he can tear down Henry's house and build a shopping center on the land to make him rich. Tom and Lucy are frantic to get home to save their family from the bulldozers. Will Tom and Lucy make it back in time to save the house and their family from the evil Uncle Augustus...?